人 CD300LF 抗体对
01AB00476
CD300 molecule like family member F (CD300LF) is an inhibitory receptor that plays a crucial role in modulating immune responses. It is expressed in myeloid cells and mast cells, where it acts to regulate the phagocytosis of apoptotic cells (efferocytosis) and maintain immune homeostasis. Specifically, CD300LF promotes macrophage clearance of self-antigens while inhibiting dendritic cell uptake and activation, thus preventing excessive immune responses. The protein contains immunoreceptor tyrosine-based inhibition motifs (ITIMs) that are essential for its inhibitory function. In disease contexts, dysregulation of CD300LF has been implicated in various pathological conditions, including autoimmune diseases and inflammatory disorders, highlighting its importance in maintaining immune balance. Overall, CD300LF is a key regulator of immune cell processes, ensuring appropriate responses to apoptotic cells and preventing autoimmune reactions.
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技术参数
- 靶点基因名
- CD300LF
- 基因别名
- CD300F; CLM1; IGSF13; IREM1; NKIR
- 蛋白别名
- CD300 molecule like family member f; CD300LF
- UniProt
- Q8TDQ1
- 物种
- Human
产品详情
- 靶点名称
- CD300LF
- 蛋白名称
- CD300 molecule like family member f
- 蛋白别名
- CMRF35-like molecule 1; CLM-1; CD300 antigen-like family member F; Immune receptor expressed on myeloid cells 1; IREM-1; Immunoglobulin superfamily member 13; IgSF13; NK inhibitory receptor; CD antigen CD300f
- 靶点基因名
- CD300LF
- 基因别名
- CD300F; CLM1; IGSF13; IREM1; NKIR
- UniProt
- Q8TDQ1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD300 molecule like family member F (CD300LF) is an inhibitory receptor that plays a crucial role in modulating immune responses. It is expressed in myeloid cells and mast cells, where it acts to regulate the phagocytosis of apoptotic cells (efferocytosis) and maintain immune homeostasis. Specifically, CD300LF promotes macrophage clearance of self-antigens while inhibiting dendritic cell uptake and activation, thus preventing excessive immune responses. The protein contains immunoreceptor tyrosine-based inhibition motifs (ITIMs) that are essential for its inhibitory function. In disease contexts, dysregulation of CD300LF has been implicated in various pathological conditions, including autoimmune diseases and inflammatory disorders, highlighting its importance in maintaining immune balance. Overall, CD300LF is a key regulator of immune cell processes, ensuring appropriate responses to apoptotic cells and preventing autoimmune reactions.