抗人 CD300E 抗体对
01AB00759
CD300e molecule (CD300E) is a type I transmembrane glycoprotein belonging to the CD300 family of immune regulatory proteins. It is expressed on the surface of monocytes, dendritic cells, and other myeloid cells. CD300E contains an extracellular immunoglobulin-like domain and associates with the signaling adaptor DAP12, enabling it to function as an activating receptor. Engagement of CD300E promotes cell survival, cytokine production, and upregulation of costimulatory molecules in myeloid cells. Recent studies have implicated CD300E in cancer progression and immune evasion. In colorectal cancer, high CD300E expression on tumor-associated macrophages correlates with an immunosuppressive tumor microenvironment and poor prognosis. CD300E-deficient macrophages exhibit enhanced pro-inflammatory and phagocytic activity.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CD300E
- 基因别名
- CD300LE; CLM2; CMRF35A5; IREM2
- 蛋白别名
- CD300e molecule; CD300E
- UniProt
- Q496F6
- 物种
- Human
产品详情
- 靶点名称
- CD300E
- 蛋白名称
- CD300e molecule
- 蛋白别名
- CMRF35-like molecule 2; CLM-2; CD300 antigen-like family member E; CMRF35-A5; Immune receptor expressed on myeloid cells 2; IREM-2; Polymeric immunoglobulin receptor 2; PIgR-2; PIgR2; Poly-Ig receptor 2; CD antigen CD300e
- 靶点基因名
- CD300E
- 基因别名
- CD300LE; CLM2; CMRF35A5; IREM2
- UniProt
- Q496F6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD300e molecule (CD300E) is a type I transmembrane glycoprotein belonging to the CD300 family of immune regulatory proteins. It is expressed on the surface of monocytes, dendritic cells, and other myeloid cells. CD300E contains an extracellular immunoglobulin-like domain and associates with the signaling adaptor DAP12, enabling it to function as an activating receptor. Engagement of CD300E promotes cell survival, cytokine production, and upregulation of costimulatory molecules in myeloid cells. Recent studies have implicated CD300E in cancer progression and immune evasion. In colorectal cancer, high CD300E expression on tumor-associated macrophages correlates with an immunosuppressive tumor microenvironment and poor prognosis. CD300E-deficient macrophages exhibit enhanced pro-inflammatory and phagocytic activity.