人 CD244 抗体对
01AB00473
CD244, also known as SLAMF4 or 2B4, is a type-I transmembrane protein in the signaling lymphocytic activation molecule (SLAM) family, primarily expressed on natural killer (NK) cells and some T cells. It features two extracellular immunoglobulin-like domains and a cytoplasmic domain with immunoreceptor tyrosine-based switch motifs (ITSMs), facilitating interactions with the ligand CD48. This interaction regulates immune responses by mediating activating or inhibitory signals, influencing NK cell cytotoxicity and cytokine production. CD244 is implicated in various diseases, including autoimmune disorders like rheumatoid arthritis and infectious diseases such as tuberculosis, where its signaling pathways can affect disease outcomes. Its role in modulating immune responses makes it a potential target for therapeutic interventions in immune-related conditions and cancer.
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技术参数
- 靶点基因名
- CD244
- 基因别名
- 2B4
- 蛋白别名
- CD244 molecule; CD244
- UniProt
- Q9BZW8
- 物种
- Human
产品详情
- 靶点名称
- CD244
- 蛋白名称
- CD244 molecule
- 蛋白别名
- Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD antigen CD244
- 靶点基因名
- CD244
- 基因别名
- 2B4
- UniProt
- Q9BZW8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD244, also known as SLAMF4 or 2B4, is a type-I transmembrane protein in the signaling lymphocytic activation molecule (SLAM) family, primarily expressed on natural killer (NK) cells and some T cells. It features two extracellular immunoglobulin-like domains and a cytoplasmic domain with immunoreceptor tyrosine-based switch motifs (ITSMs), facilitating interactions with the ligand CD48. This interaction regulates immune responses by mediating activating or inhibitory signals, influencing NK cell cytotoxicity and cytokine production. CD244 is implicated in various diseases, including autoimmune disorders like rheumatoid arthritis and infectious diseases such as tuberculosis, where its signaling pathways can affect disease outcomes. Its role in modulating immune responses makes it a potential target for therapeutic interventions in immune-related conditions and cancer.