抗人 CD239 抗体对
01AB01025
Basal cell adhesion molecule (BCAM), also known as Lutheran blood group glycoprotein or CD239, is a transmembrane glycoprotein of the immunoglobulin superfamily comprising five extracellular Ig-like domains, a single transmembrane domain, and a short cytoplasmic tail. It functions primarily as a receptor for laminin α5, an extracellular matrix protein, mediating cell adhesion, motility, migration, and invasion by interacting with laminin and cytoskeletal proteins such as spectrin. BCAM is widely expressed in red blood cells, endothelial, smooth muscle, and epithelial cells and plays a critical role in cell signaling and cytoskeletal organization. Dysregulation or abnormal expression of BCAM is implicated in several diseases, notably sickle cell anemia, where it contributes to vaso-occlusion, and various cancers including liver, lung, colorectal, bladder, and ovarian cancers, where it promotes tumor cell migration and metastasis.
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技术参数
- 靶点基因名
- BCAM
- 基因别名
- LU; MSK19
- 蛋白别名
- basal cell adhesion molecule (Lutheran blood group); CD239
- UniProt
- P50895
- 物种
- Human
产品详情
- 靶点名称
- CD239
- 蛋白名称
- basal cell adhesion molecule (Lutheran blood group)
- 蛋白别名
- Basal cell adhesion molecule; Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen; Lutheran antigen; Lutheran blood group glycoprotein; CD antigen CD239
- 靶点基因名
- BCAM
- 基因别名
- LU; MSK19
- UniProt
- P50895
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Basal cell adhesion molecule (BCAM), also known as Lutheran blood group glycoprotein or CD239, is a transmembrane glycoprotein of the immunoglobulin superfamily comprising five extracellular Ig-like domains, a single transmembrane domain, and a short cytoplasmic tail. It functions primarily as a receptor for laminin α5, an extracellular matrix protein, mediating cell adhesion, motility, migration, and invasion by interacting with laminin and cytoskeletal proteins such as spectrin. BCAM is widely expressed in red blood cells, endothelial, smooth muscle, and epithelial cells and plays a critical role in cell signaling and cytoskeletal organization. Dysregulation or abnormal expression of BCAM is implicated in several diseases, notably sickle cell anemia, where it contributes to vaso-occlusion, and various cancers including liver, lung, colorectal, bladder, and ovarian cancers, where it promotes tumor cell migration and metastasis.