人 CD22 抗体对
01AB00470
CD22 molecule (CD22), also known as SIGLEC-2, is a regulatory molecule that plays a crucial role in preventing the overactivation of the immune system and the development of autoimmune diseases. It is a transmembrane protein found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling by binding to sialic acid-containing ligands, which leads to the inhibition of BCR signaling through the association with SHP-1, a protein tyrosine phosphatase. The molecule consists of seven immunoglobulin domains in its extracellular part and a 141-amino acid cytoplasmic tail. The glycosylation of CD22 is essential for its surface expression and epitope recognition by monoclonal antibodies. CD22 is involved in B cell trafficking to Peyer's patches in mice and has been shown to restore homeostatic microglial phagocytosis in aging brains when blocked.
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技术参数
- 靶点基因名
- CD22
- 基因别名
- SIGLEC2
- 蛋白别名
- CD22 molecule; CD22
- UniProt
- P20273
- 物种
- Human
产品详情
- 靶点名称
- CD22
- 蛋白名称
- CD22 molecule
- 蛋白别名
- B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22
- 靶点基因名
- CD22
- 基因别名
- SIGLEC2
- UniProt
- P20273
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD22 molecule (CD22), also known as SIGLEC-2, is a regulatory molecule that plays a crucial role in preventing the overactivation of the immune system and the development of autoimmune diseases. It is a transmembrane protein found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling by binding to sialic acid-containing ligands, which leads to the inhibition of BCR signaling through the association with SHP-1, a protein tyrosine phosphatase. The molecule consists of seven immunoglobulin domains in its extracellular part and a 141-amino acid cytoplasmic tail. The glycosylation of CD22 is essential for its surface expression and epitope recognition by monoclonal antibodies. CD22 is involved in B cell trafficking to Peyer's patches in mice and has been shown to restore homeostatic microglial phagocytosis in aging brains when blocked.