人 CD209 抗体对
01AB01449
CD209 molecule (CD209), also known as DC-SIGN, is a C-type lectin receptor predominantly expressed on the surface of immature dendritic cells. It features a C-terminal carbohydrate recognition domain that binds mannose-like glycans in a calcium-dependent manner, facilitating high-affinity interactions with ICAM2 and ICAM3. These interactions are critical for dendritic cell adhesion, transendothelial migration, and the formation of immunological synapses to regulate T-cell proliferation. As a pathogen-recognition receptor, CD209 mediates the endocytosis of numerous microorganisms, including Mycobacterium tuberculosis and various viruses such as HIV-1, Ebola, and SARS-CoV, for antigen presentation via the MHC class II pathway. CD209 is a major factor in infectious disease pathology, as many pathogens exploit this receptor to facilitate viral trans-infection and dissemination within the host immune system.
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技术参数
- 靶点基因名
- CD209
- 基因别名
- CLEC4L
- 蛋白别名
- CD209 molecule; CD209
- UniProt
- Q9NNX6
- 物种
- Human
产品详情
- 靶点名称
- CD209
- 蛋白名称
- CD209 molecule
- 蛋白别名
- CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD antigen CD209
- 靶点基因名
- CD209
- 基因别名
- CLEC4L
- UniProt
- Q9NNX6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD209 molecule (CD209), also known as DC-SIGN, is a C-type lectin receptor predominantly expressed on the surface of immature dendritic cells. It features a C-terminal carbohydrate recognition domain that binds mannose-like glycans in a calcium-dependent manner, facilitating high-affinity interactions with ICAM2 and ICAM3. These interactions are critical for dendritic cell adhesion, transendothelial migration, and the formation of immunological synapses to regulate T-cell proliferation. As a pathogen-recognition receptor, CD209 mediates the endocytosis of numerous microorganisms, including Mycobacterium tuberculosis and various viruses such as HIV-1, Ebola, and SARS-CoV, for antigen presentation via the MHC class II pathway. CD209 is a major factor in infectious disease pathology, as many pathogens exploit this receptor to facilitate viral trans-infection and dissemination within the host immune system.