人 CD200 抗体对
01AB02133
CD200 molecule (CD200) is a type I transmembrane glycoprotein of the immunoglobulin superfamily characterized by two extracellular Ig-like domains. It is broadly expressed on B cells, T cells, neurons, and endothelial cells, and functions as a ligand for the inhibitory receptor CD200R. This interaction delivers immunosuppressive signals that down-modulate the activation of macrophages, microglia, and dendritic cells, thereby maintaining immune homeostasis and tolerance. CD200 plays a significant role in regulating anti-tumor immunity and is highly expressed in various hematologic and solid malignancies. Clinically, CD200 is a recognized marker and therapeutic target in hairy cell leukemia, chronic lymphocytic leukemia, and multiple myeloma.
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技术参数
- 靶点基因名
- CD200
- 基因别名
- MOX1; MOX2
- 蛋白别名
- CD200 molecule; CD200
- UniProt
- P41217
- 物种
- Human
产品详情
- 靶点名称
- CD200
- 蛋白名称
- CD200 molecule
- 蛋白别名
- OX-2 membrane glycoprotein; CD antigen CD200
- 靶点基因名
- CD200
- 基因别名
- MOX1; MOX2
- UniProt
- P41217
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD200 molecule (CD200) is a type I transmembrane glycoprotein of the immunoglobulin superfamily characterized by two extracellular Ig-like domains. It is broadly expressed on B cells, T cells, neurons, and endothelial cells, and functions as a ligand for the inhibitory receptor CD200R. This interaction delivers immunosuppressive signals that down-modulate the activation of macrophages, microglia, and dendritic cells, thereby maintaining immune homeostasis and tolerance. CD200 plays a significant role in regulating anti-tumor immunity and is highly expressed in various hematologic and solid malignancies. Clinically, CD200 is a recognized marker and therapeutic target in hairy cell leukemia, chronic lymphocytic leukemia, and multiple myeloma.