抗人 CD1C 抗体对
01AB00756
CD1c molecule (CD1C) is a transmembrane glycoprotein belonging to the CD1 family, structurally related to Major Histocompatibility Complex (MHC) proteins. It forms heterodimers with beta-2-microglobulin and specializes in presenting lipid and glycolipid antigens, both self and microbial, to T-cell receptors on natural killer T-cells. Unlike other CD1 isoforms, CD1c features a unique open F′ groove that allows it to accommodate diverse lipid antigens, including those with methyl-branched structures. This structural adaptation enables CD1c to bind and present antigens such as mannosyl-β1-phosphomycoketide (MPM) from Mycobacterium tuberculosis, playing a critical role in immune responses. The protein is broadly distributed throughout the endocytic system, guided by a tyrosine-based motif in its cytoplasmic tail. Diseases associated with CD1c include histiocytosis and follicular dendritic cell sarcoma.
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技术参数
- 靶点基因名
- CD1C
- 蛋白别名
- CD1c molecule; CD1C
- UniProt
- P29017
- 物种
- Human
产品详情
- 靶点名称
- CD1C
- 蛋白名称
- CD1c molecule
- 蛋白别名
- T-cell surface glycoprotein CD1c; CD antigen CD1c
- 靶点基因名
- CD1C
- UniProt
- P29017
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD1c molecule (CD1C) is a transmembrane glycoprotein belonging to the CD1 family, structurally related to Major Histocompatibility Complex (MHC) proteins. It forms heterodimers with beta-2-microglobulin and specializes in presenting lipid and glycolipid antigens, both self and microbial, to T-cell receptors on natural killer T-cells. Unlike other CD1 isoforms, CD1c features a unique open F′ groove that allows it to accommodate diverse lipid antigens, including those with methyl-branched structures. This structural adaptation enables CD1c to bind and present antigens such as mannosyl-β1-phosphomycoketide (MPM) from Mycobacterium tuberculosis, playing a critical role in immune responses. The protein is broadly distributed throughout the endocytic system, guided by a tyrosine-based motif in its cytoplasmic tail. Diseases associated with CD1c include histiocytosis and follicular dendritic cell sarcoma.