人 CD134/OX40L Receptor 抗体对
01AB02601
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as OX40, is a protein that plays a pivotal role in the immune system, particularly in T cell activation and survival. It is a member of the tumor necrosis factor receptor superfamily and is primarily expressed on activated T cells. TNFRSF4 interacts with its ligand, TNFSF4 (OX40L), which enhances T cell proliferation and cytokine production, contributing to the regulation of immune responses. Dysregulation of TNFRSF4 has been associated with various diseases, including Immunodeficiency 16 and Hemolytic Uremic Syndrome, where its altered signaling can lead to impaired immune function and increased susceptibility to infections. Additionally, TNFRSF4 is implicated in autoimmune diseases and cancer, as its expression can promote tumor growth by supporting the survival of tumor-infiltrating lymphocytes.
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技术参数
- 靶点基因名
- TNFRSF4
- 基因别名
- TXGP1L
- 蛋白别名
- TNF receptor superfamily member 4; CD134/OX40L Recepter
- UniProt
- P43489
- 物种
- Human
产品详情
- 靶点名称
- CD134/OX40L Recepter
- 蛋白名称
- TNF receptor superfamily member 4
- 蛋白别名
- Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD antigen CD134
- 靶点基因名
- TNFRSF4
- 基因别名
- TXGP1L
- UniProt
- P43489
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as OX40, is a protein that plays a pivotal role in the immune system, particularly in T cell activation and survival. It is a member of the tumor necrosis factor receptor superfamily and is primarily expressed on activated T cells. TNFRSF4 interacts with its ligand, TNFSF4 (OX40L), which enhances T cell proliferation and cytokine production, contributing to the regulation of immune responses. Dysregulation of TNFRSF4 has been associated with various diseases, including Immunodeficiency 16 and Hemolytic Uremic Syndrome, where its altered signaling can lead to impaired immune function and increased susceptibility to infections. Additionally, TNFRSF4 is implicated in autoimmune diseases and cancer, as its expression can promote tumor growth by supporting the survival of tumor-infiltrating lymphocytes.