人 CD11b 抗体对
01AB00287
Integrin subunit alpha M (ITGAM), also known as CD11b, is a protein that forms part of the heterodimeric integrin αMβ2 molecule, crucial for leukocyte adhesion and migration. ITGAM is expressed on the surface of various leukocytes, including monocytes, granulocytes, macrophages, and natural killer cells, and plays a key role in inflammation, phagocytosis, and cell-mediated cytotoxicity. The αMβ2 integrin is involved in the complement system by binding to inactivated complement component 3b (iC3b), facilitating the phagocytosis of opsonized particles. Mutations in ITGAM have been associated with systemic lupus erythematosus (SLE), cardiovascular disease, and lupus nephritis, due to impaired cell adhesion and phagocytosis. Additionally, ITGAM has been implicated in osteoarthritis, where it may contribute to joint destruction by mediating the interaction between integrins and cytokines in the extracellular matrix.
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技术参数
- 靶点基因名
- ITGAM
- 基因别名
- CD11B; CR3A
- 蛋白别名
- integrin subunit alpha M; CD11b
- UniProt
- P11215
- 物种
- Human
产品详情
- 靶点名称
- CD11b
- 蛋白名称
- integrin subunit alpha M
- 蛋白别名
- Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b
- 靶点基因名
- ITGAM
- 基因别名
- CD11B; CR3A
- UniProt
- P11215
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Integrin subunit alpha M (ITGAM), also known as CD11b, is a protein that forms part of the heterodimeric integrin αMβ2 molecule, crucial for leukocyte adhesion and migration. ITGAM is expressed on the surface of various leukocytes, including monocytes, granulocytes, macrophages, and natural killer cells, and plays a key role in inflammation, phagocytosis, and cell-mediated cytotoxicity. The αMβ2 integrin is involved in the complement system by binding to inactivated complement component 3b (iC3b), facilitating the phagocytosis of opsonized particles. Mutations in ITGAM have been associated with systemic lupus erythematosus (SLE), cardiovascular disease, and lupus nephritis, due to impaired cell adhesion and phagocytosis. Additionally, ITGAM has been implicated in osteoarthritis, where it may contribute to joint destruction by mediating the interaction between integrins and cytokines in the extracellular matrix.