人 CCN4 抗体对
01AB02711
Cellular communication network factor 4 (CCN4) is a secreted matricellular protein of the CCN/CTGF family that functions as a downstream regulator of the Wnt/Frizzled signaling pathway. It contains conserved modular domains that enable interactions with the extracellular matrix, integrins, and various growth factors to modulate cell adhesion, migration, proliferation, and differentiation. CCN4 plays a significant role in promoting cell survival and attenuating p53-mediated apoptosis following DNA damage. In pathological contexts, CCN4 is frequently upregulated in various malignancies, particularly melanoma, where it drives epithelial-mesenchymal transition, glycolysis, and metastasis. Furthermore, it contributes to tumor-induced immunosuppression by recruiting myeloid-derived suppressor cells and inhibiting the activity of CD8+ T and NK cells. These roles establish CCN4 as a key factor in tumor progression and an emerging target for therapeutic intervention.
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技术参数
- 靶点基因名
- CCN4
- 基因别名
- WISP1
- 蛋白别名
- cellular communication network factor 4; CCN4
- UniProt
- O95388
- 物种
- Human
产品详情
- 靶点名称
- CCN4
- 蛋白名称
- cellular communication network factor 4
- 蛋白别名
- CCN family member 4; WNT1-inducible-signaling pathway protein 1; WISP-1; Wnt-1-induced secreted protein
- 靶点基因名
- CCN4
- 基因别名
- WISP1
- UniProt
- O95388
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cellular communication network factor 4 (CCN4) is a secreted matricellular protein of the CCN/CTGF family that functions as a downstream regulator of the Wnt/Frizzled signaling pathway. It contains conserved modular domains that enable interactions with the extracellular matrix, integrins, and various growth factors to modulate cell adhesion, migration, proliferation, and differentiation. CCN4 plays a significant role in promoting cell survival and attenuating p53-mediated apoptosis following DNA damage. In pathological contexts, CCN4 is frequently upregulated in various malignancies, particularly melanoma, where it drives epithelial-mesenchymal transition, glycolysis, and metastasis. Furthermore, it contributes to tumor-induced immunosuppression by recruiting myeloid-derived suppressor cells and inhibiting the activity of CD8+ T and NK cells. These roles establish CCN4 as a key factor in tumor progression and an emerging target for therapeutic intervention.