人 CCN2 抗体对
01AB02636
Cellular communication network factor 2 (CCN2), also known as connective tissue growth factor, is a secreted matricellular protein that plays a central role in skeletal development, wound repair, and angiogenesis. It contains four conserved cysteine-rich modules that facilitate interactions with integrins, heparan sulfate proteoglycans, and growth factors such as VEGF and TGF-beta. CCN2 acts as a potent mitogen for connective tissue and promotes the proliferation and differentiation of chondrocytes. Pathologically, CCN2 is a primary mediator of fibrosis and is significantly overexpressed in chronic diseases of the kidney, liver, lung, and skin. It is also implicated in the progression of diabetic nephropathy, retinopathy, and various cancers, making it a key therapeutic target in clinical trials for fibrotic and vascular disorders.
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技术参数
- 靶点基因名
- CCN2
- 基因别名
- CTGF; HCS24; IGFBP8
- 蛋白别名
- cellular communication network factor 2; CCN2
- UniProt
- P29279
- 物种
- Human
产品详情
- 靶点名称
- CCN2
- 蛋白名称
- cellular communication network factor 2
- 蛋白别名
- CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
- 靶点基因名
- CCN2
- 基因别名
- CTGF; HCS24; IGFBP8
- UniProt
- P29279
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cellular communication network factor 2 (CCN2), also known as connective tissue growth factor, is a secreted matricellular protein that plays a central role in skeletal development, wound repair, and angiogenesis. It contains four conserved cysteine-rich modules that facilitate interactions with integrins, heparan sulfate proteoglycans, and growth factors such as VEGF and TGF-beta. CCN2 acts as a potent mitogen for connective tissue and promotes the proliferation and differentiation of chondrocytes. Pathologically, CCN2 is a primary mediator of fibrosis and is significantly overexpressed in chronic diseases of the kidney, liver, lung, and skin. It is also implicated in the progression of diabetic nephropathy, retinopathy, and various cancers, making it a key therapeutic target in clinical trials for fibrotic and vascular disorders.