人 CCL3 抗体对
01AB03960
C-C motif chemokine ligand 3 (CCL3), also known as macrophage inflammatory protein 1-alpha (MIP-1α), is a cytokine encoded by the CCL3 gene located on chromosome 17. It plays a crucial role in the immune response by recruiting inflammatory cells such as macrophages, monocytes, and neutrophils to sites of injury or infection through its interaction with receptors CCR1, CCR4, and CCR5. CCL3 is involved in various disease processes, particularly in hematological conditions; it has been implicated in the pathophysiology of leukemias by negatively regulating hematopoietic stem/progenitor cell proliferation, thereby influencing tumor growth and maintenance. Additionally, elevated levels of CCL3 have been associated with inflammatory diseases and conditions such as spinal cord injury, where it exacerbates secondary damage.
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技术参数
- 靶点基因名
- CCL3
- 基因别名
- G0S19-1; MIP1A; SCYA3
- 蛋白别名
- C-C motif chemokine ligand 3; CCL3
- UniProt
- P10147
- 物种
- Human
产品详情
- 靶点名称
- CCL3
- 蛋白名称
- C-C motif chemokine ligand 3
- 蛋白别名
- C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69; LD78-alpha(4-69)]
- 靶点基因名
- CCL3
- 基因别名
- G0S19-1; MIP1A; SCYA3
- UniProt
- P10147
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine ligand 3 (CCL3), also known as macrophage inflammatory protein 1-alpha (MIP-1α), is a cytokine encoded by the CCL3 gene located on chromosome 17. It plays a crucial role in the immune response by recruiting inflammatory cells such as macrophages, monocytes, and neutrophils to sites of injury or infection through its interaction with receptors CCR1, CCR4, and CCR5. CCL3 is involved in various disease processes, particularly in hematological conditions; it has been implicated in the pathophysiology of leukemias by negatively regulating hematopoietic stem/progenitor cell proliferation, thereby influencing tumor growth and maintenance. Additionally, elevated levels of CCL3 have been associated with inflammatory diseases and conditions such as spinal cord injury, where it exacerbates secondary damage.