人 CCL21 抗体对
01AB03957
C-C motif chemokine 21 (CCL21), also known as secondary lymphoid-tissue chemokine (SLC), is a small cytokine belonging to the CC chemokine family, characterized by its six conserved cysteine residues. It primarily functions as a chemotactic factor that guides CCR7-expressing leukocytes, such as T cells and dendritic cells, to secondary lymphoid organs like lymph nodes and Peyer's patches. CCL21 is constitutively expressed in these tissues but its expression can increase during inflammatory responses. Dysregulation of CCL21 has been linked to several diseases, particularly autoimmune disorders, where altered leukocyte trafficking can contribute to pathogenesis. Additionally, CCL21 has been implicated in cancer metastasis, as it may facilitate the migration of tumor-infiltrating lymphocytes and dendritic cells to lymph nodes, affecting tumor immunity.
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技术参数
- 靶点基因名
- CCL21
- 基因别名
- SCYA21
- 蛋白别名
- C-C motif chemokine ligand 21; CCL21
- UniProt
- O00585
- 物种
- Human
产品详情
- 靶点名称
- CCL21
- 蛋白名称
- C-C motif chemokine ligand 21
- 蛋白别名
- C-C motif chemokine 21; 6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
- 靶点基因名
- CCL21
- 基因别名
- SCYA21
- UniProt
- O00585
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine 21 (CCL21), also known as secondary lymphoid-tissue chemokine (SLC), is a small cytokine belonging to the CC chemokine family, characterized by its six conserved cysteine residues. It primarily functions as a chemotactic factor that guides CCR7-expressing leukocytes, such as T cells and dendritic cells, to secondary lymphoid organs like lymph nodes and Peyer's patches. CCL21 is constitutively expressed in these tissues but its expression can increase during inflammatory responses. Dysregulation of CCL21 has been linked to several diseases, particularly autoimmune disorders, where altered leukocyte trafficking can contribute to pathogenesis. Additionally, CCL21 has been implicated in cancer metastasis, as it may facilitate the migration of tumor-infiltrating lymphocytes and dendritic cells to lymph nodes, affecting tumor immunity.