人 CCL2 抗体对
01AB00127
CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a small cytokine that belongs to the CC chemokine family. It plays a crucial role in regulating cellular mechanics and recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation caused by tissue injury or infection. CCL2 is implicated in the pathogenesis of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, atherosclerosis, and various neuroinflammatory diseases of the central nervous system. The CCL2-CCR2 signaling axis has been extensively studied, as it is associated with the progression of conditions like cardiovascular disease, acute liver failure, rheumatoid arthritis, pulmonary hypertension, diabetes, and cancer. Dysregulation of CCL2 expression and the CCL2-CCR2 axis can lead to ineffective functions and cause several diseases, including adverse pregnancy outcomes like spontaneous abortion, preeclampsia, and preterm labor. Overall, CCL2 is a key player in regulating inflammatory processes and its dysregulation is implicated in the pathogenesis of a wide range of diseases.
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技术参数
- 靶点基因名
- CCL2
- 基因别名
- MCP1; SCYA2
- 蛋白别名
- C-C motif chemokine ligand 2; CCL2
- UniProt
- P13500
- 物种
- Human
产品详情
- 靶点名称
- CCL2
- 蛋白名称
- C-C motif chemokine ligand 2
- 蛋白别名
- C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
- 靶点基因名
- CCL2
- 基因别名
- MCP1; SCYA2
- UniProt
- P13500
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a small cytokine that belongs to the CC chemokine family. It plays a crucial role in regulating cellular mechanics and recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation caused by tissue injury or infection. CCL2 is implicated in the pathogenesis of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, atherosclerosis, and various neuroinflammatory diseases of the central nervous system. The CCL2-CCR2 signaling axis has been extensively studied, as it is associated with the progression of conditions like cardiovascular disease, acute liver failure, rheumatoid arthritis, pulmonary hypertension, diabetes, and cancer. Dysregulation of CCL2 expression and the CCL2-CCR2 axis can lead to ineffective functions and cause several diseases, including adverse pregnancy outcomes like spontaneous abortion, preeclampsia, and preterm labor. Overall, CCL2 is a key player in regulating inflammatory processes and its dysregulation is implicated in the pathogenesis of a wide range of diseases.