人 CCL17 抗体对
01AB03213
C-C motif chemokine ligand 17 (CCL17), also known as thymus and activation-regulated chemokine, is a secreted CC chemokine that plays a pivotal role in shaping type 2-biased immune responses. It is primarily produced by dendritic cells and other antigen-presenting cells to selectively attract CCR4- and CCR8-expressing CD4+ Th2 lymphocytes. CCL17 is essential for T-cell development in the thymus and the trafficking of mature T cells to sites of inflammation. Clinically, elevated CCL17 levels are a hallmark of Hodgkin lymphoma and various skin malignancies, where it facilitates the recruitment of Th2-rich inflammatory infiltrates. Additionally, increased circulating CCL17 is associated with cardiac hypertrophy and fibrosis, suggesting its potential as a therapeutic target in heart failure.
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技术参数
- 靶点基因名
- CCL17
- 基因别名
- SCYA17; TARC
- 蛋白别名
- C-C motif chemokine ligand 17; CCL17
- UniProt
- Q92583
- 物种
- Human
产品详情
- 靶点名称
- CCL17
- 蛋白名称
- C-C motif chemokine ligand 17
- 蛋白别名
- C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine
- 靶点基因名
- CCL17
- 基因别名
- SCYA17; TARC
- UniProt
- Q92583
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine ligand 17 (CCL17), also known as thymus and activation-regulated chemokine, is a secreted CC chemokine that plays a pivotal role in shaping type 2-biased immune responses. It is primarily produced by dendritic cells and other antigen-presenting cells to selectively attract CCR4- and CCR8-expressing CD4+ Th2 lymphocytes. CCL17 is essential for T-cell development in the thymus and the trafficking of mature T cells to sites of inflammation. Clinically, elevated CCL17 levels are a hallmark of Hodgkin lymphoma and various skin malignancies, where it facilitates the recruitment of Th2-rich inflammatory infiltrates. Additionally, increased circulating CCL17 is associated with cardiac hypertrophy and fibrosis, suggesting its potential as a therapeutic target in heart failure.