人 CCL16 抗体对
01AB01446
C-C motif chemokine ligand 16 (CCL16) is a member of the CC chemokine family, characterized by two adjacent cysteines and a canonical chemokine domain. CCL16 is a highly basic, secreted protein primarily synthesized by hepatocytes and circulates in the blood as a full-length protein, with little response to inflammatory mediators. It exhibits chemotactic activity for lymphocytes and monocytes but not neutrophils, and also displays potent myelosuppressive effects by suppressing proliferation of myeloid progenitor cells. The C-terminal extension may modulate its biological activity by limiting glycosaminoglycan binding site accessibility. Disease associations include inhibition of liver cirrhosis progression via inactivation of hepatic stellate cells and maintenance of stem cell-like properties in certain contexts.
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技术参数
- 靶点基因名
- CCL16
- 基因别名
- ILINCK; NCC4; SCYA16
- 蛋白别名
- C-C motif chemokine ligand 16; CCL16
- UniProt
- O15467
- 物种
- Human
产品详情
- 靶点名称
- CCL16
- 蛋白名称
- C-C motif chemokine ligand 16
- 蛋白别名
- C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16
- 靶点基因名
- CCL16
- 基因别名
- ILINCK; NCC4; SCYA16
- UniProt
- O15467
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine ligand 16 (CCL16) is a member of the CC chemokine family, characterized by two adjacent cysteines and a canonical chemokine domain. CCL16 is a highly basic, secreted protein primarily synthesized by hepatocytes and circulates in the blood as a full-length protein, with little response to inflammatory mediators. It exhibits chemotactic activity for lymphocytes and monocytes but not neutrophils, and also displays potent myelosuppressive effects by suppressing proliferation of myeloid progenitor cells. The C-terminal extension may modulate its biological activity by limiting glycosaminoglycan binding site accessibility. Disease associations include inhibition of liver cirrhosis progression via inactivation of hepatic stellate cells and maintenance of stem cell-like properties in certain contexts.