人 CCL11 抗体对
01AB02633
C-C motif chemokine ligand 11 (CCL11), also known as eotaxin-1, is a secreted CC chemokine that serves as a potent and selective chemoattractant for eosinophils. It primarily exerts its biological effects by binding to the G protein-coupled receptor CCR3, though it also exhibits activity at CCR2 and CCR5. CCL11 is a fundamental mediator of type 2 immune responses and is responsible for the recruitment of eosinophils to mucosal tissues during inflammation. Clinically, elevated levels of CCL11 are well-established in allergic and eosinophilic diseases, including asthma, allergic rhinitis, and atopic dermatitis. Furthermore, increased circulating CCL11 has been linked to age-related cognitive decline, reduced hippocampal neurogenesis, and various forms of neurological impairment.
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技术参数
- 靶点基因名
- CCL11
- 基因别名
- SCYA11
- 蛋白别名
- C-C motif chemokine ligand 11; CCL11
- UniProt
- P51671
- 物种
- Human
产品详情
- 靶点名称
- CCL11
- 蛋白名称
- C-C motif chemokine ligand 11
- 蛋白别名
- Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
- 靶点基因名
- CCL11
- 基因别名
- SCYA11
- UniProt
- P51671
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine ligand 11 (CCL11), also known as eotaxin-1, is a secreted CC chemokine that serves as a potent and selective chemoattractant for eosinophils. It primarily exerts its biological effects by binding to the G protein-coupled receptor CCR3, though it also exhibits activity at CCR2 and CCR5. CCL11 is a fundamental mediator of type 2 immune responses and is responsible for the recruitment of eosinophils to mucosal tissues during inflammation. Clinically, elevated levels of CCL11 are well-established in allergic and eosinophilic diseases, including asthma, allergic rhinitis, and atopic dermatitis. Furthermore, increased circulating CCL11 has been linked to age-related cognitive decline, reduced hippocampal neurogenesis, and various forms of neurological impairment.