人 CCL1 抗体对
01AB03849
C-C motif chemokine 1 (CCL1) is a small glycoprotein belonging to the chemokine family, primarily produced by activated monocytes, macrophages, and T lymphocytes. It functions as a chemotactic factor, binding to the CCR8 receptor to induce calcium influx, promote cell migration, and regulate apoptosis. CCL1 is particularly important in recruiting Th2 cells and regulatory T lymphocytes to sites of inflammation, playing a critical role in immune responses and tissue remodeling. Dysregulation of CCL1 has been implicated in several diseases, particularly in inflammatory and autoimmune conditions. For example, elevated CCL1 levels have been associated with asthma and chronic obstructive pulmonary disease (COPD), contributing to airway inflammation and remodeling. Additionally, CCL1 is overexpressed in certain cancers, such as adult T-cell leukemia (ATL), where it mediates an autocrine anti-apoptotic loop that supports leukemic cell survival.
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技术参数
- 靶点基因名
- CCL1
- 基因别名
- SCYA1
- 蛋白别名
- C-C motif chemokine ligand 1; CCL1
- UniProt
- P22362
- 物种
- Human
产品详情
- 靶点名称
- CCL1
- 蛋白名称
- C-C motif chemokine ligand 1
- 蛋白别名
- C-C motif chemokine 1; Small-inducible cytokine A1; T lymphocyte-secreted protein I-309
- 靶点基因名
- CCL1
- 基因别名
- SCYA1
- UniProt
- P22362
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-C motif chemokine 1 (CCL1) is a small glycoprotein belonging to the chemokine family, primarily produced by activated monocytes, macrophages, and T lymphocytes. It functions as a chemotactic factor, binding to the CCR8 receptor to induce calcium influx, promote cell migration, and regulate apoptosis. CCL1 is particularly important in recruiting Th2 cells and regulatory T lymphocytes to sites of inflammation, playing a critical role in immune responses and tissue remodeling. Dysregulation of CCL1 has been implicated in several diseases, particularly in inflammatory and autoimmune conditions. For example, elevated CCL1 levels have been associated with asthma and chronic obstructive pulmonary disease (COPD), contributing to airway inflammation and remodeling. Additionally, CCL1 is overexpressed in certain cancers, such as adult T-cell leukemia (ATL), where it mediates an autocrine anti-apoptotic loop that supports leukemic cell survival.