人 CCDC80 抗体对
01AB00171
Coiled-coil domain containing 80 (CCDC80) is a protein that plays significant roles in adipogenesis and cancer biology. It is predominantly expressed in white adipose tissue, where it regulates adipocyte differentiation by modulating key transcription factors such as C/EBPα and PPARγ, while also inhibiting Wnt/β-catenin signaling pathways. CCDC80 has been identified as a potential tumor suppressor, as its ectopic expression can inhibit the growth of various cancer cell lines, including melanoma and thyroid carcinomas. Additionally, CCDC80 is involved in extracellular matrix organization and cell adhesion, enhancing E-cadherin expression, which is crucial for preventing tumor invasion. Diseases associated with CCDC80 include various cancers and metabolic disorders.
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技术参数
- 靶点基因名
- CCDC80
- 基因别名
- DRO1; URB
- 蛋白别名
- coiled-coil domain containing 80; CCDC80
- UniProt
- Q76M96
- 物种
- Human
产品详情
- 靶点名称
- CCDC80
- 蛋白名称
- coiled-coil domain containing 80
- 蛋白别名
- Coiled-coil domain-containing protein 80; Down-regulated by oncogenes protein 1; Up-regulated in BRS-3 deficient mouse homolog
- 靶点基因名
- CCDC80
- 基因别名
- DRO1; URB
- UniProt
- Q76M96
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Coiled-coil domain containing 80 (CCDC80) is a protein that plays significant roles in adipogenesis and cancer biology. It is predominantly expressed in white adipose tissue, where it regulates adipocyte differentiation by modulating key transcription factors such as C/EBPα and PPARγ, while also inhibiting Wnt/β-catenin signaling pathways. CCDC80 has been identified as a potential tumor suppressor, as its ectopic expression can inhibit the growth of various cancer cell lines, including melanoma and thyroid carcinomas. Additionally, CCDC80 is involved in extracellular matrix organization and cell adhesion, enhancing E-cadherin expression, which is crucial for preventing tumor invasion. Diseases associated with CCDC80 include various cancers and metabolic disorders.