人 CCDC15 抗体对
01AB00468
Coiled-coil domain containing 15 (CCDC15) is a protein that plays a crucial role in the structural integrity and function of centrioles, which are essential for cellular processes such as cilia formation and centrosome organization. CCDC15 localizes to the inner scaffold of centrioles, where it interacts with other scaffold proteins to regulate centriole length and stability. Disruption of CCDC15 function has been linked to various diseases, most notably neurodevelopmental disorders characterized by cataracts, highlighting its importance in developmental processes and cellular signaling pathways like Hedgehog signaling. The protein's coiled-coil structure facilitates interactions with multiple partners, contributing to its regulatory functions in centriole architecture. Studies have shown that loss of CCDC15 leads to defective ciliogenesis and compromised cellular responses .
| 规格 | 起售价 |
|---|---|
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技术参数
- 靶点基因名
- CCDC15
- 蛋白别名
- coiled-coil domain containing 15; CCDC15
- UniProt
- Q0P6D6
- 物种
- Human
产品详情
- 靶点名称
- CCDC15
- 蛋白名称
- coiled-coil domain containing 15
- 蛋白别名
- Coiled-coil domain-containing protein 15
- 靶点基因名
- CCDC15
- UniProt
- Q0P6D6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Coiled-coil domain containing 15 (CCDC15) is a protein that plays a crucial role in the structural integrity and function of centrioles, which are essential for cellular processes such as cilia formation and centrosome organization. CCDC15 localizes to the inner scaffold of centrioles, where it interacts with other scaffold proteins to regulate centriole length and stability. Disruption of CCDC15 function has been linked to various diseases, most notably neurodevelopmental disorders characterized by cataracts, highlighting its importance in developmental processes and cellular signaling pathways like Hedgehog signaling. The protein's coiled-coil structure facilitates interactions with multiple partners, contributing to its regulatory functions in centriole architecture. Studies have shown that loss of CCDC15 leads to defective ciliogenesis and compromised cellular responses .