抗人 CBX4 抗体对
01AB02802
Chromobox 4 (CBX4) is a nuclear polycomb-group protein and a component of the non-canonical PRC1 complex that integrates chromatin-binding and SUMO E3 ligase activities. It contains an N-terminal chromodomain that recognizes methylated histone H3K9, mediating transcriptional repression and epigenetic control of the cell cycle, senescence, and DNA damage responses. CBX4 also functions as a SUMO ligase to regulate various transcription factors and signaling pathways, including NF-κB. Clinically, CBX4 is overexpressed in multiple malignancies, such as hepatocellular carcinoma and breast cancer, where it promotes proliferation, epithelial-mesenchymal transition, and angiogenesis, often correlating with poor patient prognosis.
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技术参数
- 靶点基因名
- CBX4
- 蛋白别名
- chromobox 4; CBX4
- UniProt
- O00257
- 物种
- Human
产品详情
- 靶点名称
- CBX4
- 蛋白名称
- chromobox 4
- 蛋白别名
- E3 SUMO-protein ligase CBX4; Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2
- 靶点基因名
- CBX4
- UniProt
- O00257
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chromobox 4 (CBX4) is a nuclear polycomb-group protein and a component of the non-canonical PRC1 complex that integrates chromatin-binding and SUMO E3 ligase activities. It contains an N-terminal chromodomain that recognizes methylated histone H3K9, mediating transcriptional repression and epigenetic control of the cell cycle, senescence, and DNA damage responses. CBX4 also functions as a SUMO ligase to regulate various transcription factors and signaling pathways, including NF-κB. Clinically, CBX4 is overexpressed in multiple malignancies, such as hepatocellular carcinoma and breast cancer, where it promotes proliferation, epithelial-mesenchymal transition, and angiogenesis, often correlating with poor patient prognosis.