抗人 CBLIF 抗体对
01AB00653
Cobalamin binding intrinsic factor (CBLIF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It plays a crucial role in the absorption of vitamin B12 (cobalamin) in the ileum of the small intestine. The protein has a single vitamin B12-binding site with a high association constant, and its interaction with cubilin is critical for the endocytosis of the CBLIF-cobalamin complex. CBLIF binds to vitamin B12, forming a complex that is then recognized and internalized by cubilin, a multiligand apical membrane protein, in the distal ileum. This process is essential for the efficient absorption of vitamin B12, as free vitamin B12 is poorly absorbed. Mutations in the CBLIF gene can lead to intrinsic factor deficiency, a rare inheritable disease characterized by malabsorption of vitamin B12 and subsequent megaloblastic anemia.
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技术参数
- 靶点基因名
- CBLIF
- 基因别名
- GIF; IFMH
- 蛋白别名
- cobalamin binding intrinsic factor; CBLIF
- UniProt
- P27352
- 物种
- Human
产品详情
- 靶点名称
- CBLIF
- 蛋白名称
- cobalamin binding intrinsic factor
- 蛋白别名
- Cobalamin binding intrinsic factor; Gastric intrinsic factor; Intrinsic factor; IF; INF
- 靶点基因名
- CBLIF
- 基因别名
- GIF; IFMH
- UniProt
- P27352
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cobalamin binding intrinsic factor (CBLIF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It plays a crucial role in the absorption of vitamin B12 (cobalamin) in the ileum of the small intestine. The protein has a single vitamin B12-binding site with a high association constant, and its interaction with cubilin is critical for the endocytosis of the CBLIF-cobalamin complex. CBLIF binds to vitamin B12, forming a complex that is then recognized and internalized by cubilin, a multiligand apical membrane protein, in the distal ileum. This process is essential for the efficient absorption of vitamin B12, as free vitamin B12 is poorly absorbed. Mutations in the CBLIF gene can lead to intrinsic factor deficiency, a rare inheritable disease characterized by malabsorption of vitamin B12 and subsequent megaloblastic anemia.