抗人 CBL 抗体对
01AB01037
CBL is a crucial regulator of cellular signaling pathways, primarily functioning as an E3 ubiquitin ligase that mediates the degradation of activated receptor tyrosine kinases (RTKs) through ubiquitination. This process is vital for maintaining cellular homeostasis and preventing aberrant signaling, which can lead to oncogenesis. Mutations or dysregulation of CBL have been implicated in various cancers, including acute myeloid leukemia, colorectal cancer, and breast cancer, where its loss of function contributes to sustained RTK signaling and tumor progression. Specifically, CBL mutations can result in the activation of oncogenic pathways, as seen in myeloproliferative neoplasms, where inactivated CBL mutants disrupt normal cellular processes and promote oncogenic transformations. Additionally, CBL's role in diseases like Noonan syndrome highlights its importance beyond cancer, indicating a broader impact on cellular signaling and development.
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技术参数
- 靶点基因名
- CBL
- 基因别名
- CBL2; RNF55
- 蛋白别名
- Cbl proto-oncogene; CBL
- UniProt
- P22681
- 物种
- Human
产品详情
- 靶点名称
- CBL
- 蛋白名称
- Cbl proto-oncogene
- 蛋白别名
- E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBL
- 靶点基因名
- CBL
- 基因别名
- CBL2; RNF55
- UniProt
- P22681
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CBL is a crucial regulator of cellular signaling pathways, primarily functioning as an E3 ubiquitin ligase that mediates the degradation of activated receptor tyrosine kinases (RTKs) through ubiquitination. This process is vital for maintaining cellular homeostasis and preventing aberrant signaling, which can lead to oncogenesis. Mutations or dysregulation of CBL have been implicated in various cancers, including acute myeloid leukemia, colorectal cancer, and breast cancer, where its loss of function contributes to sustained RTK signaling and tumor progression. Specifically, CBL mutations can result in the activation of oncogenic pathways, as seen in myeloproliferative neoplasms, where inactivated CBL mutants disrupt normal cellular processes and promote oncogenic transformations. Additionally, CBL's role in diseases like Noonan syndrome highlights its importance beyond cancer, indicating a broader impact on cellular signaling and development.