人 Cathepsin S 抗体对
01AB03998
Cathepsin S (CTSS) is a lysosomal cysteine protease that plays a pivotal role in protein degradation and antigen processing, particularly in the context of major histocompatibility complex (MHC) class II-mediated immune responses. It is synthesized as an inactive precursor and activated within lysosomes, where it cleaves proteins into peptides for presentation to T cells. Beyond its role in the immune system, cathepsin S is involved in extracellular matrix remodeling and has been implicated in various pathological conditions. Dysregulation of CTSS expression has been associated with several diseases, including cancer, where it can promote tumor progression by facilitating cell invasion and metastasis, and autoimmune diseases, where overactivity may lead to inappropriate immune responses. Additionally, elevated levels of cathepsin S have been linked to cardiovascular diseases due to its involvement in inflammation and tissue remodeling.
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技术参数
- 靶点基因名
- CTSS
- 蛋白别名
- cathepsin S; Cathepsin S
- UniProt
- P25774
- 物种
- Human
产品详情
- 靶点名称
- Cathepsin S
- 蛋白名称
- cathepsin S
- 蛋白别名
- Cathepsin S
- 靶点基因名
- CTSS
- UniProt
- P25774
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cathepsin S (CTSS) is a lysosomal cysteine protease that plays a pivotal role in protein degradation and antigen processing, particularly in the context of major histocompatibility complex (MHC) class II-mediated immune responses. It is synthesized as an inactive precursor and activated within lysosomes, where it cleaves proteins into peptides for presentation to T cells. Beyond its role in the immune system, cathepsin S is involved in extracellular matrix remodeling and has been implicated in various pathological conditions. Dysregulation of CTSS expression has been associated with several diseases, including cancer, where it can promote tumor progression by facilitating cell invasion and metastasis, and autoimmune diseases, where overactivity may lead to inappropriate immune responses. Additionally, elevated levels of cathepsin S have been linked to cardiovascular diseases due to its involvement in inflammation and tissue remodeling.