人 Cathepsin H 抗体对
01AB00794
Cathepsin H (CTSH) is a lysosomal cysteine protease that plays a crucial role in the degradation of proteins within lysosomes. It is synthesized as an inactive precursor and undergoes proteolytic activation, resulting in a mature form that exhibits both aminopeptidase and endopeptidase activities. This protein is composed of disulfide-linked heavy and light chains and is involved in various physiological processes, including protein turnover and immune responses. The enzyme's activity is optimal at neutral pH, allowing it to function effectively in both lysosomal and extracellular environments. Increased expression of CTSH has been associated with the progression of several cancers, including prostate and breast cancer, where it influences tumor cell behavior by modulating integrin activation and cell migration.
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技术参数
- 靶点基因名
- CTSH
- 基因别名
- CPSB
- 蛋白别名
- cathepsin H; Cathepsin H
- UniProt
- P09668
- 物种
- Human
产品详情
- 靶点名称
- Cathepsin H
- 蛋白名称
- cathepsin H
- 蛋白别名
- Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain]
- 靶点基因名
- CTSH
- 基因别名
- CPSB
- UniProt
- P09668
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cathepsin H (CTSH) is a lysosomal cysteine protease that plays a crucial role in the degradation of proteins within lysosomes. It is synthesized as an inactive precursor and undergoes proteolytic activation, resulting in a mature form that exhibits both aminopeptidase and endopeptidase activities. This protein is composed of disulfide-linked heavy and light chains and is involved in various physiological processes, including protein turnover and immune responses. The enzyme's activity is optimal at neutral pH, allowing it to function effectively in both lysosomal and extracellular environments. Increased expression of CTSH has been associated with the progression of several cancers, including prostate and breast cancer, where it influences tumor cell behavior by modulating integrin activation and cell migration.