人 CAT 抗体对
01AB00168
Catalase (CAT) is an enzyme that catalyzes the conversion of hydrogen peroxide to water and oxygen, playing a crucial role in protecting cells from oxidative stress. It is a tetrameric enzyme consisting of four identical subunits, each containing a heme group and NADPH. The heme group, specifically the porphyrin-heme Fe group, reacts with hydrogen peroxide to facilitate this conversion. Catalase has two enzymatic activities: catalatic, which removes hydrogen peroxide by forming water and oxygen at high concentrations, and peroxidatic, which oxidizes substrates like ethanol and phenol at low concentrations. Mutations in catalase can lead to resistance to certain drugs, such as isoniazid, and are associated with various diseases including neurodegenerative disorders and cancer due to increased oxidative stress. Overall, catalase is an efficient and stable enzyme essential for cellular protection against reactive oxygen species.
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技术参数
- 靶点基因名
- CAT
- 蛋白别名
- catalase; CAT
- UniProt
- P04040
- 物种
- Human
产品详情
- 靶点名称
- CAT
- 蛋白名称
- catalase
- 蛋白别名
- Catalase
- 靶点基因名
- CAT
- UniProt
- P04040
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Catalase (CAT) is an enzyme that catalyzes the conversion of hydrogen peroxide to water and oxygen, playing a crucial role in protecting cells from oxidative stress. It is a tetrameric enzyme consisting of four identical subunits, each containing a heme group and NADPH. The heme group, specifically the porphyrin-heme Fe group, reacts with hydrogen peroxide to facilitate this conversion. Catalase has two enzymatic activities: catalatic, which removes hydrogen peroxide by forming water and oxygen at high concentrations, and peroxidatic, which oxidizes substrates like ethanol and phenol at low concentrations. Mutations in catalase can lead to resistance to certain drugs, such as isoniazid, and are associated with various diseases including neurodegenerative disorders and cancer due to increased oxidative stress. Overall, catalase is an efficient and stable enzyme essential for cellular protection against reactive oxygen species.