人 Caspase-9 抗体对
01AB00465
Caspase 9 (CASP9) is a crucial enzyme in the intrinsic or mitochondrial pathway of apoptosis, playing a pivotal role in programmed cell death. It is activated when cytochrome c is released from the mitochondria in response to various forms of stress or death signals. Structurally, CASP9 consists of an N-terminal caspase recruiting domain (CARD), a large subunit (p35), a linker region containing the caspase cleavage sites, and a small subunit (p10). Upon activation, it forms a heterotetramer composed of two anti-parallel arranged heterodimers, each consisting of a p35 and a p10 subunit. CASP9 is involved in various pathological conditions, including cancer, where it can be activated by chemotherapies, stress agents, and radiation.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CASP9
- 基因别名
- MCH6
- 蛋白别名
- caspase 9; Caspase-9
- UniProt
- P55211
- 物种
- Human
产品详情
- 靶点名称
- Caspase-9
- 蛋白名称
- caspase 9
- 蛋白别名
- Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
- 靶点基因名
- CASP9
- 基因别名
- MCH6
- UniProt
- P55211
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase 9 (CASP9) is a crucial enzyme in the intrinsic or mitochondrial pathway of apoptosis, playing a pivotal role in programmed cell death. It is activated when cytochrome c is released from the mitochondria in response to various forms of stress or death signals. Structurally, CASP9 consists of an N-terminal caspase recruiting domain (CARD), a large subunit (p35), a linker region containing the caspase cleavage sites, and a small subunit (p10). Upon activation, it forms a heterotetramer composed of two anti-parallel arranged heterodimers, each consisting of a p35 and a p10 subunit. CASP9 is involved in various pathological conditions, including cancer, where it can be activated by chemotherapies, stress agents, and radiation.