抗人 Caspase-8 抗体对
01AB02980
Caspase-8 (CASP8) is a critical initiator caspase that plays a central role in the extrinsic apoptosis pathway triggered by death receptors such as Fas and TRAIL receptors. It contains tandem death effector domains (DEDs) in its prodomain and an active protease domain at the C-terminus. Upon activation by oligomerization, caspase-8 cleaves and activates downstream effector caspases like caspase-3 to execute apoptosis. Beyond its pro-apoptotic function, caspase-8 also has roles in cell survival, inflammation, and suppression of necrosis. Mutations in CASP8 have been associated with various diseases, particularly head and neck squamous cell carcinomas (HNSCCs) where they can influence TRAIL-mediated apoptosis and cytokine induction. Additionally, a rare genetic disorder called CEDS (caspase eight deficiency state) is caused by CASP8 mutations, leading to immunodeficiency and features similar to autoimmune lymphoproliferative syndrome (ALPS).
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技术参数
- 靶点基因名
- CASP8
- 基因别名
- MCH5
- 蛋白别名
- caspase 8; Caspase-8
- UniProt
- Q14790
- 物种
- Human
产品详情
- 靶点名称
- Caspase-8
- 蛋白名称
- caspase 8
- 蛋白别名
- Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
- 靶点基因名
- CASP8
- 基因别名
- MCH5
- UniProt
- Q14790
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase-8 (CASP8) is a critical initiator caspase that plays a central role in the extrinsic apoptosis pathway triggered by death receptors such as Fas and TRAIL receptors. It contains tandem death effector domains (DEDs) in its prodomain and an active protease domain at the C-terminus. Upon activation by oligomerization, caspase-8 cleaves and activates downstream effector caspases like caspase-3 to execute apoptosis. Beyond its pro-apoptotic function, caspase-8 also has roles in cell survival, inflammation, and suppression of necrosis. Mutations in CASP8 have been associated with various diseases, particularly head and neck squamous cell carcinomas (HNSCCs) where they can influence TRAIL-mediated apoptosis and cytokine induction. Additionally, a rare genetic disorder called CEDS (caspase eight deficiency state) is caused by CASP8 mutations, leading to immunodeficiency and features similar to autoimmune lymphoproliferative syndrome (ALPS).