人 Caspase-14 抗体对
01AB03847
Caspase-14 (CASP14) is a unique member of the caspase family, primarily involved in the regulation of keratinocyte differentiation and the formation of the skin barrier. Unlike other caspases that primarily mediate apoptosis, CASP14 plays a crucial role in a non-apoptotic form of programmed cell death known as cornification, which is essential for the development of the epidermis. The protein is expressed predominantly in the upper layers of the skin, where it is activated through proteolytic cleavage by other caspases, such as caspase-8 and caspase-10. Dysregulation of CASP14 has been implicated in various skin disorders, including atopic dermatitis and other keratinization disorders, where impaired cornification can lead to barrier dysfunction and increased susceptibility to infections.
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技术参数
- 靶点基因名
- CASP14
- 蛋白别名
- caspase 14; Caspase-14
- UniProt
- P31944
- 物种
- Human
产品详情
- 靶点名称
- Caspase-14
- 蛋白名称
- caspase 14
- 蛋白别名
- Caspase-14; CASP-14) [Cleaved into: Caspase-14 subunit p17; mature form; Caspase-14 subunit p10; mature form; Caspase-14 subunit p20; intermediate form; Caspase-14 subunit p8; intermediate form]
- 靶点基因名
- CASP14
- UniProt
- P31944
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase-14 (CASP14) is a unique member of the caspase family, primarily involved in the regulation of keratinocyte differentiation and the formation of the skin barrier. Unlike other caspases that primarily mediate apoptosis, CASP14 plays a crucial role in a non-apoptotic form of programmed cell death known as cornification, which is essential for the development of the epidermis. The protein is expressed predominantly in the upper layers of the skin, where it is activated through proteolytic cleavage by other caspases, such as caspase-8 and caspase-10. Dysregulation of CASP14 has been implicated in various skin disorders, including atopic dermatitis and other keratinization disorders, where impaired cornification can lead to barrier dysfunction and increased susceptibility to infections.