人 Caspase-10 抗体对
01AB04252
Caspase 10 (CASP10) is a member of the cysteine-aspartic acid protease (caspase) family, playing a crucial role in the execution phase of cell apoptosis. It is encoded by the CASP10 gene and exists as an inactive proenzyme that undergoes proteolytic processing to produce two subunits that dimerize to form the active enzyme. The protein itself is processed by caspase 8 and cleaves and activates caspases 3 and 7, highlighting its central role in the apoptosis pathway. The protein contains two death effector domains (DED) and is involved in the activation cascade of caspases responsible for apoptosis execution, interacting with FADD, CFLAR, Caspase 8, and other proteins. Mutations in the CASP10 gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome, a condition characterized by an overactive immune response and lymphoproliferation.
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技术参数
- 靶点基因名
- CASP10
- 基因别名
- MCH4
- 蛋白别名
- caspase 10; Caspase-10
- UniProt
- Q92851
- 物种
- Human
产品详情
- 靶点名称
- Caspase-10
- 蛋白名称
- caspase 10
- 蛋白别名
- Caspase-10; CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
- 靶点基因名
- CASP10
- 基因别名
- MCH4
- UniProt
- Q92851
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase 10 (CASP10) is a member of the cysteine-aspartic acid protease (caspase) family, playing a crucial role in the execution phase of cell apoptosis. It is encoded by the CASP10 gene and exists as an inactive proenzyme that undergoes proteolytic processing to produce two subunits that dimerize to form the active enzyme. The protein itself is processed by caspase 8 and cleaves and activates caspases 3 and 7, highlighting its central role in the apoptosis pathway. The protein contains two death effector domains (DED) and is involved in the activation cascade of caspases responsible for apoptosis execution, interacting with FADD, CFLAR, Caspase 8, and other proteins. Mutations in the CASP10 gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome, a condition characterized by an overactive immune response and lymphoproliferation.