抗人 Caspase-1 抗体对
01AB02948
Caspase-1 (CASP1) is a cytosolic cysteine-aspartate protease and the central effector of the inflammasome complex. Synthesized as an inactive zymogen, it is recruited to inflammasome adaptors via its CARD domain, where it undergoes autoproteolytic activation. Active Caspase-1 cleaves the pro-forms of the inflammatory cytokines IL-1β and IL-18 into their biologically active secreted states, initiating potent inflammatory responses. Additionally, it cleaves gasdermin D to induce pyroptosis, a lytic form of cell death. Dysregulated Caspase-1 activity is a hallmark of autoinflammatory diseases, septic shock, and neurodegenerative conditions, driving chronic inflammation and tissue damage.
| 规格 | 起售价 |
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技术参数
- 靶点基因名
- CASP1
- 基因别名
- IL1BC; IL1BCE
- 蛋白别名
- caspase 1; Caspase-1
- UniProt
- P29466
- 物种
- Human
产品详情
- 靶点名称
- Caspase-1
- 蛋白名称
- caspase 1
- 蛋白别名
- Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
- 靶点基因名
- CASP1
- 基因别名
- IL1BC; IL1BCE
- UniProt
- P29466
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase-1 (CASP1) is a cytosolic cysteine-aspartate protease and the central effector of the inflammasome complex. Synthesized as an inactive zymogen, it is recruited to inflammasome adaptors via its CARD domain, where it undergoes autoproteolytic activation. Active Caspase-1 cleaves the pro-forms of the inflammatory cytokines IL-1β and IL-18 into their biologically active secreted states, initiating potent inflammatory responses. Additionally, it cleaves gasdermin D to induce pyroptosis, a lytic form of cell death. Dysregulated Caspase-1 activity is a hallmark of autoinflammatory diseases, septic shock, and neurodegenerative conditions, driving chronic inflammation and tissue damage.