人心肌肌钙蛋白 C 抗体对
01AB03835
The TNNC1 gene encodes for Troponin C（cTnC）, a protein crucial for muscle contraction by binding calcium. Troponin C is part of the troponin complex found in striated muscle, including cardiac and slow skeletal muscle. It plays a key role in activating muscle contraction by binding calcium ions. Mutations in the TNNC1 gene have been associated with conditions like dilated cardiomyopathy. The gene is located on chromosome 3p21.3-3p14.3 in humans. Troponin C has a regulatory N-terminal domain and a structural C-terminal domain, each containing EF-hand motifs for calcium binding. In cardiac muscle, Troponin C interacts with other troponin subunits to regulate muscle contraction. Studies have shown that Troponin C is highly conserved and plays a critical role in understanding heart failure, cardiomyopathies, and the development of cardiac drugs.
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|---|---|
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技术参数
- 靶点基因名
- TNNC1
- 基因别名
- TNNC
- 蛋白别名
- troponin C1, slow skeletal and cardiac type; Cardiac Troponin C
- UniProt
- P63316
- 物种
- Human
产品详情
- 靶点名称
- Cardiac Troponin C
- 蛋白名称
- troponin C1, slow skeletal and cardiac type
- 蛋白别名
- Troponin C; slow skeletal and cardiac muscles; TN-C
- 靶点基因名
- TNNC1
- 基因别名
- TNNC
- UniProt
- P63316
- 来源物种
- /
背景介绍
The TNNC1 gene encodes for Troponin C（cTnC）, a protein crucial for muscle contraction by binding calcium. Troponin C is part of the troponin complex found in striated muscle, including cardiac and slow skeletal muscle. It plays a key role in activating muscle contraction by binding calcium ions. Mutations in the TNNC1 gene have been associated with conditions like dilated cardiomyopathy. The gene is located on chromosome 3p21.3-3p14.3 in humans. Troponin C has a regulatory N-terminal domain and a structural C-terminal domain, each containing EF-hand motifs for calcium binding. In cardiac muscle, Troponin C interacts with other troponin subunits to regulate muscle contraction. Studies have shown that Troponin C is highly conserved and plays a critical role in understanding heart failure, cardiomyopathies, and the development of cardiac drugs.