人 CARD14 抗体对
01AB01445
Caspase recruitment domain family member 14 (CARD14) is a scaffold protein belonging to the membrane-associated guanylate kinase (MAGUK) family and the CARD-CC protein family, characterized by a caspase-associated recruitment domain (CARD) and a coiled-coil (CC) domain. CARD14 is primarily expressed in the skin, where it plays a crucial role in assembling multiprotein complexes at specialized plasma membrane regions and activating the NF-κB signaling pathway, which regulates genes involved in immune responses, inflammation, and cell survival. The protein interacts with BCL10 and MALT1 to form a CBM signalosome, facilitating NF-κB activation and modulating skin cell homeostasis, including the regulation of filaggrin (FLG) expression. Pathogenic mutations in CARD14 are associated with several skin disorders, most notably psoriasis and pityriasis rubra pilaris, as well as atopic eczema, due to dysregulated inflammatory signaling in the skin.
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技术参数
- 靶点基因名
- CARD14
- 基因别名
- CARMA2
- 蛋白别名
- caspase recruitment domain family member 14; CARD14
- UniProt
- Q9BXL6
- 物种
- Human
产品详情
- 靶点名称
- CARD14
- 蛋白名称
- caspase recruitment domain family member 14
- 蛋白别名
- Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2
- 靶点基因名
- CARD14
- 基因别名
- CARMA2
- UniProt
- Q9BXL6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Caspase recruitment domain family member 14 (CARD14) is a scaffold protein belonging to the membrane-associated guanylate kinase (MAGUK) family and the CARD-CC protein family, characterized by a caspase-associated recruitment domain (CARD) and a coiled-coil (CC) domain. CARD14 is primarily expressed in the skin, where it plays a crucial role in assembling multiprotein complexes at specialized plasma membrane regions and activating the NF-κB signaling pathway, which regulates genes involved in immune responses, inflammation, and cell survival. The protein interacts with BCL10 and MALT1 to form a CBM signalosome, facilitating NF-κB activation and modulating skin cell homeostasis, including the regulation of filaggrin (FLG) expression. Pathogenic mutations in CARD14 are associated with several skin disorders, most notably psoriasis and pityriasis rubra pilaris, as well as atopic eczema, due to dysregulated inflammatory signaling in the skin.