人 CAPSL 抗体对
01AB00746
Calcyphosine like (CAPSL) is a calcium-binding protein implicated in microtubule dynamics during mitosis. It promotes spindle formation by bundling microtubules into kinetochore fibers (k-fibers), facilitating chromosome segregation and satisfaction of the spindle assembly checkpoint. CAPSL binds tubulin in a calcium-dependent manner, and its crystal structure reveals calcium-induced conformational changes that regulate protein interactions. Elevated CAPSL expression is observed in various cancers, suggesting a role in cell proliferation, although overexpression has limited effects on the cell cycle. On the disease front, CAPSL dysfunction has been linked to familial exudative vitreoretinopathy (FEVR), a genetic disorder impairing retinal angiogenesis. This occurs through dysregulation of the MYC signaling axis.
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技术参数
- 靶点基因名
- CAPSL
- 蛋白别名
- calcyphosine like; CAPSL
- UniProt
- Q8WWF8
- 物种
- Human
产品详情
- 靶点名称
- CAPSL
- 蛋白名称
- calcyphosine like
- 蛋白别名
- Calcyphosin-like protein
- 靶点基因名
- CAPSL
- UniProt
- Q8WWF8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Calcyphosine like (CAPSL) is a calcium-binding protein implicated in microtubule dynamics during mitosis. It promotes spindle formation by bundling microtubules into kinetochore fibers (k-fibers), facilitating chromosome segregation and satisfaction of the spindle assembly checkpoint. CAPSL binds tubulin in a calcium-dependent manner, and its crystal structure reveals calcium-induced conformational changes that regulate protein interactions. Elevated CAPSL expression is observed in various cancers, suggesting a role in cell proliferation, although overexpression has limited effects on the cell cycle. On the disease front, CAPSL dysfunction has been linked to familial exudative vitreoretinopathy (FEVR), a genetic disorder impairing retinal angiogenesis. This occurs through dysregulation of the MYC signaling axis.