抗人 CAMKK1 抗体对
01AB00743
Calcium/calmodulin dependent protein kinase kinase 1 (CAMKK1) is a serine/threonine kinase belonging to the Ca2+/calmodulin-dependent protein kinase (CAMK) family, characterized by a kinase domain with an N-terminal lobe of β-strands and a predominantly α-helical C-terminal lobe. It contains an auto-inhibitory domain overlapping with a calmodulin-binding domain at the C-terminus, which keeps the enzyme inactive until calcium/calmodulin binding activates it. CAMKK1 functions as an upstream kinase in the calcium-triggered signaling cascade, phosphorylating and activating downstream kinases such as CAMK1 and CAMK4, thereby regulating transcription factors, cell cycle, hormone production, neurite outgrowth, and actin cytoskeleton organization. Structural studies have revealed its ATP-binding pocket and interactions with potent inhibitors, aiding selective drug design. Dysregulation of CAMKK1 is implicated in neurological disorders due to its role in neuronal maturation, axon elongation, and long-term memory formation. Additionally, CAMKK1 is involved in cardiovascular signaling pathways and may contribute to disease states related to calcium signaling abnormalities.
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技术参数
- 靶点基因名
- CAMKK1
- 基因别名
- CAMKKA
- 蛋白别名
- calcium/calmodulin dependent protein kinase kinase 1; CAMKK1
- UniProt
- Q8N5S9
- 物种
- Human
产品详情
- 靶点名称
- CAMKK1
- 蛋白名称
- calcium/calmodulin dependent protein kinase kinase 1
- 蛋白别名
- Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
- 靶点基因名
- CAMKK1
- 基因别名
- CAMKKA
- UniProt
- Q8N5S9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Calcium/calmodulin dependent protein kinase kinase 1 (CAMKK1) is a serine/threonine kinase belonging to the Ca2+/calmodulin-dependent protein kinase (CAMK) family, characterized by a kinase domain with an N-terminal lobe of β-strands and a predominantly α-helical C-terminal lobe. It contains an auto-inhibitory domain overlapping with a calmodulin-binding domain at the C-terminus, which keeps the enzyme inactive until calcium/calmodulin binding activates it. CAMKK1 functions as an upstream kinase in the calcium-triggered signaling cascade, phosphorylating and activating downstream kinases such as CAMK1 and CAMK4, thereby regulating transcription factors, cell cycle, hormone production, neurite outgrowth, and actin cytoskeleton organization. Structural studies have revealed its ATP-binding pocket and interactions with potent inhibitors, aiding selective drug design. Dysregulation of CAMKK1 is implicated in neurological disorders due to its role in neuronal maturation, axon elongation, and long-term memory formation. Additionally, CAMKK1 is involved in cardiovascular signaling pathways and may contribute to disease states related to calcium signaling abnormalities.