抗人 CADM3 抗体对
01AB00651
Cell Adhesion Molecule 3 (CADM3) is a protein encoded by the CADM3 gene, which plays a crucial role in cell-cell adhesion, particularly in neural tissues. It is a member of the CADM family and is expressed in axons, where it interacts primarily with CADM4 to facilitate axon guidance, myelination, and maintenance of axonal architecture. CADM3 exhibits calcium-independent homophilic and heterophilic cell-cell adhesion activities, and its interaction with other proteins like DLG3, PALS2, and CASK suggests its involvement in membrane-associated guanylate kinase (MAGUK) subfamily member-binding activity. Mutations in the CADM3 gene have been associated with Charcot-Marie-Tooth disease type 2FF (CMT2FF), a neurodegenerative disorder characterized by axonal degeneration and demyelination. Specifically, a Y172C substitution in the extracellular domain of CADM3 has been identified as a causative mutation for CMT2FF, leading to structural protein rearrangement and impaired cell adhesion.
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技术参数
- 靶点基因名
- CADM3
- 基因别名
- IGSF4B; NECL1; SYNCAM3; TSLL1
- 蛋白别名
- cell adhesion molecule 3; CADM3
- UniProt
- Q8N126
- 物种
- Human
产品详情
- 靶点名称
- CADM3
- 蛋白名称
- cell adhesion molecule 3
- 蛋白别名
- Cell adhesion molecule 3; Brain immunoglobulin receptor; Immunoglobulin superfamily member 4B; IgSF4B; Nectin-like protein 1; NECL-1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like protein 1; TSLL1
- 靶点基因名
- CADM3
- 基因别名
- IGSF4B; NECL1; SYNCAM3; TSLL1
- UniProt
- Q8N126
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cell Adhesion Molecule 3 (CADM3) is a protein encoded by the CADM3 gene, which plays a crucial role in cell-cell adhesion, particularly in neural tissues. It is a member of the CADM family and is expressed in axons, where it interacts primarily with CADM4 to facilitate axon guidance, myelination, and maintenance of axonal architecture. CADM3 exhibits calcium-independent homophilic and heterophilic cell-cell adhesion activities, and its interaction with other proteins like DLG3, PALS2, and CASK suggests its involvement in membrane-associated guanylate kinase (MAGUK) subfamily member-binding activity. Mutations in the CADM3 gene have been associated with Charcot-Marie-Tooth disease type 2FF (CMT2FF), a neurodegenerative disorder characterized by axonal degeneration and demyelination. Specifically, a Y172C substitution in the extracellular domain of CADM3 has been identified as a causative mutation for CMT2FF, leading to structural protein rearrangement and impaired cell adhesion.