人 CA5A 抗体对
01AB04247
Carbonic anhydrase 5A (CA5A) is a mitochondrial enzyme that plays a crucial role in maintaining acid-base balance by catalyzing the reversible hydration of carbon dioxide to bicarbonate. This reaction is vital for various metabolic processes, particularly in the liver, where CA5A supports other enzymes involved in energy production and the urea cycle, which detoxifies ammonia. The enzyme's properties include a high catalytic efficiency and a unique active site structure compared to other carbonic anhydrases, involving cysteine residues instead of histidine. Deficiencies in CA5A due to mutations in the CA5A gene can lead to carbonic anhydrase VA deficiency, a rare inherited disorder characterized by severe metabolic crises, including poor feeding, rapid breathing, and seizures, particularly in infancy.
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技术参数
- 靶点基因名
- CA5A
- 基因别名
- CA5
- 蛋白别名
- carbonic anhydrase 5A; CA5A
- UniProt
- P35218
- 物种
- Human
产品详情
- 靶点名称
- CA5A
- 蛋白名称
- carbonic anhydrase 5A
- 蛋白别名
- Carbonic anhydrase 5A; mitochondrial; Carbonate dehydratase VA; Carbonic anhydrase VA; CA-VA
- 靶点基因名
- CA5A
- 基因别名
- CA5
- UniProt
- P35218
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Carbonic anhydrase 5A (CA5A) is a mitochondrial enzyme that plays a crucial role in maintaining acid-base balance by catalyzing the reversible hydration of carbon dioxide to bicarbonate. This reaction is vital for various metabolic processes, particularly in the liver, where CA5A supports other enzymes involved in energy production and the urea cycle, which detoxifies ammonia. The enzyme's properties include a high catalytic efficiency and a unique active site structure compared to other carbonic anhydrases, involving cysteine residues instead of histidine. Deficiencies in CA5A due to mutations in the CA5A gene can lead to carbonic anhydrase VA deficiency, a rare inherited disorder characterized by severe metabolic crises, including poor feeding, rapid breathing, and seizures, particularly in infancy.