人 CA3 抗体对
01AB04242
Carbonic anhydrase 3 (CA3) is a cytosolic enzyme belonging to the carbonic anhydrase family, primarily expressed in skeletal muscle. It catalyzes the reversible hydration of carbon dioxide (CO₂) to bicarbonate and protons, contributing to pH regulation, ion transport, and possibly muscle contraction. With a molecular weight of ~29.5 kDa, CA3 exhibits lower catalytic activity compared to isoforms like CA2, attributed to structural differences in its active site. CA3 also acts as a scavenger of reactive carbonyl species under oxidative stress, suggesting a protective role. CA3 is linked to metabolic myopathies, including rhabdomyolysis and myoglobinuria, where mutations or deficiencies may impair muscle energy metabolism, exacerbating exercise-induced oxidative stress. Its dysregulation is associated with susceptibility to malignant hyperthermia and muscle degeneration, emphasizing its role in maintaining muscle homeostasis.
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技术参数
- 靶点基因名
- CA3
- 蛋白别名
- carbonic anhydrase 3; CA3
- UniProt
- P07451
- 物种
- Human
产品详情
- 靶点名称
- CA3
- 蛋白名称
- carbonic anhydrase 3
- 蛋白别名
- Carbonic anhydrase 3; Carbonate dehydratase III; Carbonic anhydrase III; CA-III
- 靶点基因名
- CA3
- UniProt
- P07451
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Carbonic anhydrase 3 (CA3) is a cytosolic enzyme belonging to the carbonic anhydrase family, primarily expressed in skeletal muscle. It catalyzes the reversible hydration of carbon dioxide (CO₂) to bicarbonate and protons, contributing to pH regulation, ion transport, and possibly muscle contraction. With a molecular weight of ~29.5 kDa, CA3 exhibits lower catalytic activity compared to isoforms like CA2, attributed to structural differences in its active site. CA3 also acts as a scavenger of reactive carbonyl species under oxidative stress, suggesting a protective role. CA3 is linked to metabolic myopathies, including rhabdomyolysis and myoglobinuria, where mutations or deficiencies may impair muscle energy metabolism, exacerbating exercise-induced oxidative stress. Its dysregulation is associated with susceptibility to malignant hyperthermia and muscle degeneration, emphasizing its role in maintaining muscle homeostasis.