人 C3 抗体对
01AB02575
Complement C3 (C3) is a critical protein in the immune system, primarily involved in the complement cascade, which enhances the ability of antibodies and phagocytic cells to clear pathogens. C3 is synthesized mainly in the liver and is the most abundant complement protein in serum. Upon activation, C3 is cleaved into C3a and C3b; C3b acts as an opsonin, marking pathogens for destruction, while C3a promotes inflammation. Deficiencies in C3 can lead to severe immunocompromised states, increasing susceptibility to bacterial infections and autoimmune diseases, such as systemic lupus erythematosus (SLE) and glomerulonephritis. Elevated C3 levels are often seen in inflammatory conditions, including infections and certain malignancies. The dual role of C3 in both promoting immune responses and its involvement in pathological conditions underscores its significance in health and disease.
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技术参数
- 靶点基因名
- C3
- 基因别名
- CPAMD1
- 蛋白别名
- complement C3; C3
- UniProt
- P01024
- 物种
- Human
产品详情
- 靶点名称
- C3
- 蛋白名称
- complement C3
- 蛋白别名
- Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c; C3bc; Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein; ASP; C3adesArg; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
- 靶点基因名
- C3
- 基因别名
- CPAMD1
- UniProt
- P01024
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Complement C3 (C3) is a critical protein in the immune system, primarily involved in the complement cascade, which enhances the ability of antibodies and phagocytic cells to clear pathogens. C3 is synthesized mainly in the liver and is the most abundant complement protein in serum. Upon activation, C3 is cleaved into C3a and C3b; C3b acts as an opsonin, marking pathogens for destruction, while C3a promotes inflammation. Deficiencies in C3 can lead to severe immunocompromised states, increasing susceptibility to bacterial infections and autoimmune diseases, such as systemic lupus erythematosus (SLE) and glomerulonephritis. Elevated C3 levels are often seen in inflammatory conditions, including infections and certain malignancies. The dual role of C3 in both promoting immune responses and its involvement in pathological conditions underscores its significance in health and disease.