抗人 C10orf90 抗体对
01AB02936
Chromosome 10 open reading frame 90 (C10orf90) is an atypical E2/E3-independent ubiquitin ligase that functions as a fragile-site associated tumor suppressor. It is located within the common fragile site FRA10F and plays a critical role in the DNA damage response by binding to histone deacetylase HDAC1 and stabilizing p53 and CDKN1A/p21. These interactions enhance cell-cycle arrest and genomic stability in response to replication stress. C10orf90 is expressed across multiple tissues, including the testis, lung, and brain. Clinically, the gene is frequently downregulated or deleted in various malignancies, and its loss is associated with increased susceptibility and poor prognosis in colorectal, non-small cell lung, and breast cancers.
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技术参数
- 靶点基因名
- C10orf90
- 基因别名
- FATS
- 蛋白别名
- chromosome 10 open reading frame 90; C10orf90
- UniProt
- Q96M02
- 物种
- Human
产品详情
- 靶点名称
- C10orf90
- 蛋白名称
- chromosome 10 open reading frame 90
- 蛋白别名
- (E2-independent) E3 ubiquitin-conjugating enzyme FATS; Centrosomal protein C10orf90; E2/E3 hybrid ubiquitin-protein ligase FATS; Fragile-site associated tumor suppressor homolog; FATS
- 靶点基因名
- C10orf90
- 基因别名
- FATS
- UniProt
- Q96M02
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chromosome 10 open reading frame 90 (C10orf90) is an atypical E2/E3-independent ubiquitin ligase that functions as a fragile-site associated tumor suppressor. It is located within the common fragile site FRA10F and plays a critical role in the DNA damage response by binding to histone deacetylase HDAC1 and stabilizing p53 and CDKN1A/p21. These interactions enhance cell-cycle arrest and genomic stability in response to replication stress. C10orf90 is expressed across multiple tissues, including the testis, lung, and brain. Clinically, the gene is frequently downregulated or deleted in various malignancies, and its loss is associated with increased susceptibility and poor prognosis in colorectal, non-small cell lung, and breast cancers.