人 c-Jun 抗体对
01AB03268
Transcription factor Jun (JUN), also known as c-Jun, is a key component of the activator protein 1 (AP-1) transcription factor complex, which regulates various cellular processes including proliferation, differentiation, and apoptosis. JUN is encoded by the JUN proto-oncogene and functions as a transcriptional regulator by forming homo- or heterodimers with other proteins like c-Fos. It is activated through phosphorylation by several kinases, including JNK (c-Jun N-terminal kinase), which enhances its transcriptional activity. Dysregulation of JUN has been implicated in numerous diseases, particularly cancer. Overexpression of c-Jun is frequently observed in aggressive tumors, such as non-small cell lung cancer and breast cancer, where it promotes survival and proliferation of malignant cells. Furthermore, aberrant JUN signaling contributes to inflammatory diseases and neurodegenerative disorders.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- JUN
- 蛋白别名
- Jun proto-oncogene, AP-1 transcription factor subunit; c-Jun
- UniProt
- P05412
- 物种
- Human
产品详情
- 靶点名称
- c-Jun
- 蛋白名称
- Jun proto-oncogene, AP-1 transcription factor subunit
- 蛋白别名
- Transcription factor Jun; Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
- 靶点基因名
- JUN
- UniProt
- P05412
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transcription factor Jun (JUN), also known as c-Jun, is a key component of the activator protein 1 (AP-1) transcription factor complex, which regulates various cellular processes including proliferation, differentiation, and apoptosis. JUN is encoded by the JUN proto-oncogene and functions as a transcriptional regulator by forming homo- or heterodimers with other proteins like c-Fos. It is activated through phosphorylation by several kinases, including JNK (c-Jun N-terminal kinase), which enhances its transcriptional activity. Dysregulation of JUN has been implicated in numerous diseases, particularly cancer. Overexpression of c-Jun is frequently observed in aggressive tumors, such as non-small cell lung cancer and breast cancer, where it promotes survival and proliferation of malignant cells. Furthermore, aberrant JUN signaling contributes to inflammatory diseases and neurodegenerative disorders.