抗人 BTN3A2 抗体对
01AB02964
Butyrophilin subfamily 3 member A2 (BTN3A2) is a type I transmembrane protein encoded by the BTN3A2 gene located on chromosome 6. It plays a significant role in the immune system, particularly in the activation of Vγ9Vδ2 T cells, which are crucial for immune responses against infections and tumors. BTN3A2 lacks the B30.2 domain found in other butyrophilins but contains one V-type immunoglobulin-like domain, contributing to its function in immune modulation. Elevated expression of BTN3A2 has been associated with various diseases, including Systemic Lupus Erythematosus and ovarian cancer, where it may enhance immune co-stimulation and influence T-cell proliferation and cytokine production. The protein's structure allows it to interact with specific antibodies, further elucidating its role in immune signaling pathways.
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技术参数
- 靶点基因名
- BTN3A2
- 基因别名
- BT3.2; BTF3; BTF4
- 蛋白别名
- butyrophilin subfamily 3 member A2; BTN3A2
- UniProt
- P78410
- 物种
- Human
产品详情
- 靶点名称
- BTN3A2
- 蛋白名称
- butyrophilin subfamily 3 member A2
- 蛋白别名
- Butyrophilin subfamily 3 member A2
- 靶点基因名
- BTN3A2
- 基因别名
- BT3.2; BTF3; BTF4
- UniProt
- P78410
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Butyrophilin subfamily 3 member A2 (BTN3A2) is a type I transmembrane protein encoded by the BTN3A2 gene located on chromosome 6. It plays a significant role in the immune system, particularly in the activation of Vγ9Vδ2 T cells, which are crucial for immune responses against infections and tumors. BTN3A2 lacks the B30.2 domain found in other butyrophilins but contains one V-type immunoglobulin-like domain, contributing to its function in immune modulation. Elevated expression of BTN3A2 has been associated with various diseases, including Systemic Lupus Erythematosus and ovarian cancer, where it may enhance immune co-stimulation and influence T-cell proliferation and cytokine production. The protein's structure allows it to interact with specific antibodies, further elucidating its role in immune signaling pathways.