人 BTC 抗体对
01AB04239
Betacellulin (BTC) is a protein belonging to the epidermal growth factor (EGF) family, encoded by the BTC gene. It functions as a ligand for the epidermal growth factor receptor (EGFR) and plays a crucial role in various biological processes, including the differentiation of pancreatic β-cells, neural stem cell proliferation, and retinal vascular permeability. BTC is synthesized as a transmembrane precursor that is processed to a mature molecule by proteolytic events, resulting in a soluble form that can bind and activate ErbB receptors. The protein is associated with several diseases, notably type 2 diabetes and squamous cell carcinoma, and has been explored in gene therapy to address metabolic issues in diabetic models. BTC's molecular functions include growth factor activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, and protein tyrosine kinase activity.
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技术参数
- 靶点基因名
- BTC
- 蛋白别名
- betacellulin; BTC
- UniProt
- P35070
- 物种
- Human
产品详情
- 靶点名称
- BTC
- 蛋白名称
- betacellulin
- 蛋白别名
- Probetacellulin [Cleaved into: Betacellulin; BTC]
- 靶点基因名
- BTC
- UniProt
- P35070
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Betacellulin (BTC) is a protein belonging to the epidermal growth factor (EGF) family, encoded by the BTC gene. It functions as a ligand for the epidermal growth factor receptor (EGFR) and plays a crucial role in various biological processes, including the differentiation of pancreatic β-cells, neural stem cell proliferation, and retinal vascular permeability. BTC is synthesized as a transmembrane precursor that is processed to a mature molecule by proteolytic events, resulting in a soluble form that can bind and activate ErbB receptors. The protein is associated with several diseases, notably type 2 diabetes and squamous cell carcinoma, and has been explored in gene therapy to address metabolic issues in diabetic models. BTC's molecular functions include growth factor activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, and protein tyrosine kinase activity.