人 BOC 抗体对
01AB01437
Brother of CDO (BOC) is a cell surface receptor encoded by the BOC gene, belonging to the immunoglobulin superfamily and characterized by multiple fibronectin type III repeats, which localize it to the plasma membrane and axonal growth cones. BOC forms complexes with its homolog CDON and participates in a positive feedback loop with myogenic transcription factors, notably MyoD, to promote myogenic differentiation; it also interacts with ABL and activates JNK, thereby supporting neuronal differentiation and neurite outgrowth. The protein’s expression is tightly regulated during development and is downregulated by oncogenic Ras, which blocks differentiation, but forced re-expression of BOC can restore differentiation programs in muscle and neuronal cells. Disease associations primarily involve its role in tumorigenesis, as altered BOC expression or function can disrupt normal differentiation pathways, contributing to the development and progression of cancers such as rhabdomyosarcoma and potentially other malignancies where cell adhesion and differentiation are dysregulated.
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技术参数
- 靶点基因名
- BOC
- 蛋白别名
- BOC cell adhesion associated, oncogene regulated; BOC
- UniProt
- Q9BWV1
- 物种
- Human
产品详情
- 靶点名称
- BOC
- 蛋白名称
- BOC cell adhesion associated, oncogene regulated
- 蛋白别名
- Brother of CDO; Protein BOC
- 靶点基因名
- BOC
- UniProt
- Q9BWV1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Brother of CDO (BOC) is a cell surface receptor encoded by the BOC gene, belonging to the immunoglobulin superfamily and characterized by multiple fibronectin type III repeats, which localize it to the plasma membrane and axonal growth cones. BOC forms complexes with its homolog CDON and participates in a positive feedback loop with myogenic transcription factors, notably MyoD, to promote myogenic differentiation; it also interacts with ABL and activates JNK, thereby supporting neuronal differentiation and neurite outgrowth. The protein’s expression is tightly regulated during development and is downregulated by oncogenic Ras, which blocks differentiation, but forced re-expression of BOC can restore differentiation programs in muscle and neuronal cells. Disease associations primarily involve its role in tumorigenesis, as altered BOC expression or function can disrupt normal differentiation pathways, contributing to the development and progression of cancers such as rhabdomyosarcoma and potentially other malignancies where cell adhesion and differentiation are dysregulated.