人 BNIP3L 抗体对
01AB04237
BCL2 interacting protein 3 like (BNIP3L) is a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. It interacts with anti-apoptotic proteins, including BCL2, and plays a crucial role in mitochondrial quality control and clearance during erythroid development. BNIP3L, along with BNIP3, mediates mitochondrial clearance by opening a pore in the mitochondrial double membrane, allowing for the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. This process is essential for maintaining mitochondrial integrity and preventing cellular damage. BNIP3L is associated with diseases such as hereditary leiomyomatosis and renal cell cancer, and its dysregulation can lead to various pathological conditions. The protein's interaction with necroptosis-associated kinase RIPK3 also suggests a role in necroptosis, a form of programmed cell death.
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技术参数
- 靶点基因名
- BNIP3L
- 基因别名
- BNIP3A; BNIP3H; NIX
- 蛋白别名
- BCL2 interacting protein 3 like; BNIP3L
- UniProt
- O60238
- 物种
- Human
产品详情
- 靶点名称
- BNIP3L
- 蛋白名称
- BCL2 interacting protein 3 like
- 蛋白别名
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L
- 靶点基因名
- BNIP3L
- 基因别名
- BNIP3A; BNIP3H; NIX
- UniProt
- O60238
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BCL2 interacting protein 3 like (BNIP3L) is a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. It interacts with anti-apoptotic proteins, including BCL2, and plays a crucial role in mitochondrial quality control and clearance during erythroid development. BNIP3L, along with BNIP3, mediates mitochondrial clearance by opening a pore in the mitochondrial double membrane, allowing for the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. This process is essential for maintaining mitochondrial integrity and preventing cellular damage. BNIP3L is associated with diseases such as hereditary leiomyomatosis and renal cell cancer, and its dysregulation can lead to various pathological conditions. The protein's interaction with necroptosis-associated kinase RIPK3 also suggests a role in necroptosis, a form of programmed cell death.