抗人 BIRC2 抗体对
01AB02954
Baculoviral IAP repeat-containing protein 2 (BIRC2), also known as c-IAP1, is a member of the inhibitor of apoptosis (IAP) family, characterized by the presence of multiple baculoviral IAP repeats (BIR) and a RING finger domain. BIRC2 functions primarily as an E3 ubiquitin ligase, playing a critical role in regulating apoptosis by inhibiting caspase activation and promoting cell survival. It is involved in various cellular processes, including cell proliferation, inflammation, and immune responses. Dysregulation of BIRC2 has been implicated in several diseases, particularly cancer; its overexpression is often associated with tumorigenesis and resistance to chemotherapy in various malignancies, including colorectal and breast cancers. Additionally, BIRC2 has been linked to autoimmune diseases, where its regulatory effects on apoptosis can contribute to the survival of autoreactive lymphocytes.
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技术参数
- 靶点基因名
- BIRC2
- 基因别名
- API1; MIHB; RNF48
- 蛋白别名
- baculoviral IAP repeat containing 2; BIRC2
- UniProt
- Q13490
- 物种
- Human
产品详情
- 靶点名称
- BIRC2
- 蛋白名称
- baculoviral IAP repeat containing 2
- 蛋白别名
- Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis 1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; hIAP-2; hIAP2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2
- 靶点基因名
- BIRC2
- 基因别名
- API1; MIHB; RNF48
- UniProt
- Q13490
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Baculoviral IAP repeat-containing protein 2 (BIRC2), also known as c-IAP1, is a member of the inhibitor of apoptosis (IAP) family, characterized by the presence of multiple baculoviral IAP repeats (BIR) and a RING finger domain. BIRC2 functions primarily as an E3 ubiquitin ligase, playing a critical role in regulating apoptosis by inhibiting caspase activation and promoting cell survival. It is involved in various cellular processes, including cell proliferation, inflammation, and immune responses. Dysregulation of BIRC2 has been implicated in several diseases, particularly cancer; its overexpression is often associated with tumorigenesis and resistance to chemotherapy in various malignancies, including colorectal and breast cancers. Additionally, BIRC2 has been linked to autoimmune diseases, where its regulatory effects on apoptosis can contribute to the survival of autoreactive lymphocytes.