人 BIK 抗体对
01AB03947
Bcl-2-interacting killer (BIK) is a pro-apoptotic protein and a member of the BH3-only subfamily of Bcl-2 proteins, which are critical regulators of apoptosis. Encoded by the BIK gene, this protein is primarily localized in the endoplasmic reticulum and plays a crucial role in promoting cell death by interacting with anti-apoptotic proteins such as Bcl-2 and Bcl-xL, thereby facilitating the release of cytochrome c from mitochondria and activating downstream caspases. Dysregulation of BIK has been implicated in various diseases, particularly cancers, where its expression is often suppressed due to chromosomal deletions or epigenetic modifications. In tumors, reduced BIK levels can lead to increased cell survival and resistance to chemotherapy.
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技术参数
- 靶点基因名
- BIK
- 基因别名
- NBK
- 蛋白别名
- BCL2 interacting killer; BIK
- UniProt
- Q13323
- 物种
- Human
产品详情
- 靶点名称
- BIK
- 蛋白名称
- BCL2 interacting killer
- 蛋白别名
- Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4
- 靶点基因名
- BIK
- 基因别名
- NBK
- UniProt
- Q13323
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Bcl-2-interacting killer (BIK) is a pro-apoptotic protein and a member of the BH3-only subfamily of Bcl-2 proteins, which are critical regulators of apoptosis. Encoded by the BIK gene, this protein is primarily localized in the endoplasmic reticulum and plays a crucial role in promoting cell death by interacting with anti-apoptotic proteins such as Bcl-2 and Bcl-xL, thereby facilitating the release of cytochrome c from mitochondria and activating downstream caspases. Dysregulation of BIK has been implicated in various diseases, particularly cancers, where its expression is often suppressed due to chromosomal deletions or epigenetic modifications. In tumors, reduced BIK levels can lead to increased cell survival and resistance to chemotherapy.