人 BEX4 抗体对
01AB01924
Brain expressed X-linked 4 (BEX4) is a cytoplasmic protein and member of the BEX family primarily enriched in neural tissues. It plays a critical role in regulating microtubule deacetylation by inhibiting the deacetylase activity of SIRT2 toward α-tubulin, thereby influencing cell-cycle progression and maintaining genomic stability. Additionally, BEX4 acts as a zinc-dependent pseudosubstrate for the CRL2(FEM1B) E3 ligase complex, modulating substrate recognition and redox-sensitive signaling pathways. In clinical contexts, BEX4 is differentially expressed in glioblastoma, where its levels correlate with overall survival and contribute to radioresistance through the activation of the YAP/TAZ signaling pathway.
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技术参数
- 靶点基因名
- BEX4
- 基因别名
- BEXL1; NADE3
- 蛋白别名
- brain expressed X-linked 4; BEX4
- UniProt
- Q9NWD9
- 物种
- Human
产品详情
- 靶点名称
- BEX4
- 蛋白名称
- brain expressed X-linked 4
- 蛋白别名
- Protein BEX4; BEX1-like protein 1; Brain-expressed X-linked protein 4; Nerve growth factor receptor-associated protein 3
- 靶点基因名
- BEX4
- 基因别名
- BEXL1; NADE3
- UniProt
- Q9NWD9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Brain expressed X-linked 4 (BEX4) is a cytoplasmic protein and member of the BEX family primarily enriched in neural tissues. It plays a critical role in regulating microtubule deacetylation by inhibiting the deacetylase activity of SIRT2 toward α-tubulin, thereby influencing cell-cycle progression and maintaining genomic stability. Additionally, BEX4 acts as a zinc-dependent pseudosubstrate for the CRL2(FEM1B) E3 ligase complex, modulating substrate recognition and redox-sensitive signaling pathways. In clinical contexts, BEX4 is differentially expressed in glioblastoma, where its levels correlate with overall survival and contribute to radioresistance through the activation of the YAP/TAZ signaling pathway.