人 Beta Amyloid 1-42 抗体对

靶点名称

Beta Amyloid 1-42

蛋白名称

amyloid beta precursor protein

蛋白别名

Amyloid-beta precursor protein; APP; ABPP; APPI; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta; A4) precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II) [Cleaved into: N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-secretase C-terminal fragment; Beta-CTF; Amyloid-beta protein 42; Abeta42; Beta-APP42; Amyloid-beta protein 40; Abeta40; Beta-APP40; C83; Alpha-secretase C-terminal fragment; Alpha-CTF; P3(42; P3(40; C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); C31]

靶点基因名

APP

基因别名

A4; AD1

UniProt

P05067

来源物种

Homo sapiens (Human)

物种反应性

Human

背景介绍

The Aβ1-42 peptide is a 42-amino acid fragment cleaved from the amyloid precursor protein (APP) by secretase enzymes. It is the longer and more amyloidogenic form of the Aβ peptide, compared to the more common Aβ1-40 form. Aβ1-42 has a greater tendency to aggregate and form amyloid fibrils and plaques in the brain, which is a hallmark pathological feature of Alzheimer's disease. Increased production and accumulation of Aβ1-42 relative to Aβ1-40 is associated with genetic mutations, certain ApoE alleles, and other as-yet undiscovered factors that increase the risk of Alzheimer's disease. Measurement of the Aβ1-42 peptide in cerebrospinal fluid (CSF) is used as a biomarker for Alzheimer's disease, as decreased CSF Aβ1-42 levels indicate increased brain deposition of the peptide.The Aβ1-42/Aβ1-40 ratio in CSF is considered a more sensitive and specific marker of Alzheimer's pathology than Aβ1-42 alone.